Ammonia → HCID 13569202, compound

HRID 745917Notes

Reaction equation

HRID 745917 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15](OCC)=[O:16])=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[NH3:22]>C(O)C>[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15]([NH2:22])=[O:16])=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13569180HCID 13569180, compound

Product 1

HCID 13569202HCID 13569202, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 4-[2-(1-imidazolyl)ethoxy]phenoxyacetate free base (1.0 g), ethanol (10 ml) and concentrated ammonia solution (20 ml) was allowed to stand at room temperature for 20 hours to give a clear solution. The solution was evaporated and the residue was crystallized twice from 2-butanone to give 4-[2-(1-imidazolyl)ethoxy]phenoxyacetamide (0.38 g), m.p. 123°-124° C. Found: C, 59.70; H, 5.77; N, 16.26. C13H15N3O3 requires: C, 59.76; H, 5.79; N, 16.08%.

Workup

  1. customto give a clear solution
  2. customThe solution was evaporated
  3. customthe residue was crystallized twice from 2-butanone

Sources & evidence

ORD record
ord-2df010efd1d1418a9eec24be4b68f92f
Source dataset
uspto-grants-1986_07
Patent number
US04602016

Reaction notes

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