Sodium periodate → HCID 178515176, compound

HRID 745945Notes

Reaction equation

HRID 745945 reaction equation
[C:1]1([N:7]2[C:15](=[O:16])[C:14]3[C:9]([C:10]4[CH2:20][S:19][CH2:18][CH2:17][C:11]=4[NH:12][CH:13]=3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.I([O-])(=O)(=O)=[O:22].[Na+]>CO.O>[O:22]=[S:19]1[CH2:18][CH2:17][C:11]2[NH:12][CH:13]=[C:14]3[C:15](=[O:16])[N:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:8]=[C:9]3[C:10]=2[CH2:20]1

Participants

5

Reactant 2

HCID 23667635Sodium periodateHCID 178515175HCID 178515175, compound

Product 1

HCID 178515176HCID 178515176, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 0.3 g of 2,3,5,6,7,9-hexahydro-2-phenylthiopyrano[4,3-b]pyrazolo[3,4-d]pyridin-3-one in 200 mL of methanol, a solution of 0.8 g of sodium metaperiodate in 25 mL of water is added. The mixture is stirred at room temperature for 48 hours, then evaporated to dryness. The residue is washed with 50 mL of water, filtered, and dried in a vacuum oven at 80° overnight obtaining 2,3,5,6,7,9-hexahydro-8-oxo-2-phenylthiopyrano[4,3-b]pyrazolo[3,4-d]pyridin-3-one, m.p. 218°-220° (dec).

Workup

  1. customevaporated to dryness
  2. washThe residue is washed with 50 mL of water
  3. filtrationfiltered
  4. customdried in a vacuum oven at 80° overnight

Sources & evidence

ORD record
ord-636fd14678094cd895da8d1bd5431813
Source dataset
uspto-grants-1986_07
Patent number
US04602014

Reaction notes

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