1H-1,2,4-Triazole → HCID 14129401, compound

HRID 745963Notes

Reaction equation

HRID 745963 reaction equation
[C:1]1([C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:9]2[S:13][N:12]=[CH:11][CH:10]=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:20]1[CH:24]=[N:23][CH:22]=[N:21]1>>[C:1]1([C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([N:20]2[CH:24]=[N:23][CH:22]=[N:21]2)[C:9]2[S:13][N:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 3731134HCID 3731134, compound

Product 1

HCID 14129401HCID 14129401, compoundYield 28%

Procedure

Following the procedure of Example 1, 1.5 g of α,α-diphenyl-5-isothiazolemethanol were converted to the corresponding chloro compound and treated with 1.5 g of 1,2,4-triazole to provide 0.5 g of the title product, m.p. 235°-240° C.

Sources & evidence

ORD record
ord-e1fe6fba456c435c94bb9c88788af146
Source dataset
uspto-grants-1986_07
Patent number
US04602025

Reaction notes

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