HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trichloroacetyl isocyanate → HCID 14556140, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trichloroacetyl isocyanate | HCID 76400 | — |
| Reactant | 3-(Hydroxymethyl)-7-{[1-hydroxy-2-(thiophen-2-yl)ethylidene]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | HCID 93015 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 14556140 | HCID 14556140 | — |
Reaction Steps
Trichloroacetylisocyanate (4.3 ml) was added rapidly to a stirred suspension of (6R,7R)-3-hydroxymethyl-7-(2-thienylacetamido)ceph-3-em-4-carboxylic acid (10.62 g) at 6° in ethyl acetate (70 ml). The reaction mixture was stirred at 5° for 40 min. Petroleum ether was added dropwise during 15 min. The mixture was stirred for 30 min, filtered and the solid was washed with petroleum ether and dried to give the title compound as a solid (16.48 g), [α]D22 +73° (c 1.2 in Me2SO).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04602012 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-b961cb4450504efd8ca8a78f04f61b05 |
| Source note | uspto-grants-1986_07 |