HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 1-(6-Chloro-2H-1-benzopyran-3-yl)-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 6-Chloro-3-(1H-imidazol-1-yl)-3,4-dihydro-2H-1-benzopyran-4-ol | HCID 12953648 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(6-Chloro-2H-1-benzopyran-3-yl)-1H-imidazole | HCID 13287815 | 77.8% |
Reaction Steps
A solution of 3-(1-imidazolyl)-2,3-dihydro-6-chloro-4H-1-benzopyran-4-ol (5.4 g), acetic acid (81 ml) and sulphuric acid (27 ml) was heated at 80° C. for 8 hours. The solution, poured into ice water (200 ml), neutralized with NH4OH, extracted with CH2Cl2, dried and evaporated to dryness gave 3.9 g of 3-(1-imidazolyl)-6-chloro-2H-1-benzopyran, m.p. 118°-120° C. (isopropyl alcohol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04602022 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-229b80a24b61461cb5adff4a4362e198 |
| Source note | uspto-grants-1986_07 |