HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Chloro-3-(1H-imidazol-1-yl)-3,4-dihydro-2H-1-benzopyran-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 6-Chloro-3-(1H-imidazol-1-yl)chroman-4-one | HCID 12953639 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Chloro-3-(1H-imidazol-1-yl)-3,4-dihydro-2H-1-benzopyran-4-ol | HCID 12953648 | 99.2% |
Reaction Steps
NaBH4 (1 g) was added portionwise to a solution of 3-(1-imidazolyl)-2,3-dihydro-6-chloro-4H-1-benzopyran-4-one (2.7 g) in MeOH (70 ml) at 5°-10° C. The mixture, stirred at room temperature for 2 hours, added with water (300 ml), extracted with CHCl3, dried and evaporated to dryness gave (2.7 g) 3-(1-imidazolyl)-2,3-dihydro-6-chloro-4H-1-benzopyran-4-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04602022 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-b6e61a1e299e489280d1388b271e0bf8 |
| Source note | uspto-grants-1986_07 |