Hydrochloric Acid → HCID 13656096, compound

Participants

Reaction Steps

3.70g (9.10 mmol) of ethyl 2-[[3-(4-chlorophenyl)1,2-benzisoxazol-6-yl]sulfonyl]-2-methylpropionate was combined with 50 ml of methanol in a flask. The mixture was heated to reflux and an excess (50 ml) of 10% NaOH was added. Initially after the addition, the solution was clear yellow but after a few minutes a precipitate began to form. After refluxing for about one hour, the mixture was cooled and acidified with dilute HCl. The precipitate was collected and recrystallized from methanol to yield 3.27 g of 2-[[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]sulfonyl]-2-methylpropionic acid, m.p. 235°-239° C., with decomposition.

Provenance & Evidence