Sodium Hydroxide → HCID 13656107, compound

Participants

Reaction Steps

4.9 g (12.3 mmol) of ethyl[[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]sulfonyl]acetate was added to 500 ml of methanol and 40 ml of 15% aqueous NaOH was added to the suspension. A yellow solution resulted and within 15 minutes a creamy precipitate formed. After stirring four hours at room temperature the reaction mixture was poured into an ice/dilute HCl mixture and the precipitate was filtered, dried, and recrystallized from toluene to afford a white solid, 2.5 g of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]sulfonyl]acetic acid , m.p. 204° C.

Provenance & Evidence