Trifluoroacetic acid → HCID 56620230, compound

Participants

Reaction Conditions

Reaction Steps

3 g of tert-butyl (1R,trans ΔZ) 3-(2-methoxy-2-cyanoethenyl)-2,2-dimethyl-cyclopropane carboxylate were dissolved in 60 ml of methylene chloride and 14.6 ml of trifluoroacetic acid were introduced slowly at 0° C. with stirring for 3 hours at 0° C. The mixture was evaporated to dryness by distillation under reduced pressure and cyclohexane was added to the residue. The mixture was again evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with a mixture of hexane and ethyl acetate (4/6) yielded 2.05 g of (1R,trans,ΔZ) 3-(2-methoxy-2-cyanoethenyl)-2,2-dimethyl-cyclopropane carboxylic acid melting at 110° C.

Provenance & Evidence