HCID 178513146, compound → HCID 178478835, compound

Participants

Reaction Steps

A hot solution of stannous chloride dihydrate (12.8 g, 56.7 mmol) in concentrated hydrochloric acid (15 cm3) was slowly added to a hot stirred solution of (2,6-dichloro-3-nitrobenzylideneamino)-guanidine (2.0 g, 7.2 mmol) in glacial acetic acid (20 cm3). The solution was cooled and the precipitated white solid collected, dissolved in methanol (30 cm3) and the solution saturated with hydrogen sulphide. After filtering off the inorganic salts the filtrate was concentrated and then diluted with diethyl ether to yield a white solid which was recrystallised from methanol-diethyl ether affording (3-amino-2,6-dichlorobenzylideneamino)-guanidine dihydrochloride (1.4 g) m.p. 218°-220° C. (dec).

Provenance & Evidence