Nitric Acid → HCID 178513093, compound

Participants

Reaction Steps

Concentrated sulphuric acid (25 cm3) was added dropwise to cooled concentrated nitric acid (25 cm3), followed by (2,6-dichlorophenylacetyl)-guanidine (2.5 g 8.9 mmol) and the mixture stirred at 0° to 5° C. for 2.5 h. After pouring onto ice (600 g) the mixture was neutralised with sodium hydroxide solution and the precipitated cream solid collected and recrystallised from aqueous methanol affording pale yellow plates of (2,6-dichloro-3-nitrophenylacetyl)-guanidine (2.1 g) m.p. 198°-9° C. (dec). The corresponding hydrochloride was prepared by dissolving the base in hot ethanolic hydrogen chloride. The cooled solution yielded the hydrochloride as a white solid.

Provenance & Evidence