反应详情

0.40 g (2.0 mmol) 3-bromobenzoic acid and 0.28 g (2.0 mmol) 5-fluoro-2,3-dihydro-1H-indole in 0.55 mL (4.0 mmol) TEA and 10 mL DCM were combined with 0.64 mg (2.0 mmol) TBTU and stirred overnight at RT. The reaction mixture was extracted with saturated sodium hydrogen carbonate solution and DCM. The combined organic phases were dried on sodium sulphate, filtered and evaporated down. The residue was suspended in MeOH, suction filtered and dried.

1. extractionThe reaction mixture was extracted with saturated sodium hydrogen carbonate solution and DCM
2. customThe combined organic phases were dried on sodium sulphate
3. filtrationfiltered
4. customevaporated down
5. filtrationsuction filtered
6. customdried