Acetic Acid → HCID 67002033, compound

Participants

Reaction Steps

As shown in Method E, imidazole 10 (R8 =CH3) is treated with any ether cleaving reagent such as 48% HBr in acetic acid, pyridine-HCl, AlCl3 /C6H6, and BBr3 /CH2Cl2 at 0° to the reflux temperature of the solvent for about 1-24 hours to obtain imidazole phenol 11 (X=CH2). Imidazole 10 (R8 =CH2C6H5) is treated with a suitable solvent such as an alcohol (CH3OH, EtOH, and the like) or acetic acid at ambient temperature for a period of about 15 minutes to about 15 hours in the presence of a suitable catalyst such as 10% Pd on carbon, platinum oxide, and the like, at a pressure of up to about 60 psi to afford imidazole 11 (X=CH2 or X=O when m and n are >1). ##STR16##

Provenance & Evidence