Triethylamine → HCID 20240709, compound

Participants

Reaction Steps

7.8 g (0.05 mol) of 1,3-dimethylbarbituric acid and 14 g (0.05 mol) of 4-(3,5-dichloropyrid-2-yloxy)phenylisocyanate are suspended in 50 ml of xylene. 1 g of triethylamine is added dropwise to the suspension and the temperature rises to 45°-50° C. After further addition of 50 ml of xylene the mixture is stirred for 18 hours at this temperature. Then 1/3 of the xylene is distilled off. After cooling, the precipitate is isolated by filtration, washed with xylene, suspended several times in HCl and the suspension is thoroughly washed with water and dried, affording 1,3-dimethyl-5-[4-(3,5-dichloropyrid-2-yloxy)phenylcarbamoyl]barbituric acid of the formula ##STR25## with a melting point of 234°-235° C.

Provenance & Evidence