Diethylcarbamoyl chloride → HCID 70445405, compound

Participants

Reaction Steps

76 g of triethylamine and, thereafter, 68 g of diethylcarbamyl chloride were added dropwise to 58.5 g of 4-methyl-5-chloroimidazole in 200 ml of chloroform in a stirred flask provided with a thermometer and reflux condenser. Refluxing was then carried out for 2 hours, after which the mixture was cooled and the precipitated triethylamine hydrochloride was filtered off under suction. The filtrate was evaporated down under reduced pressure, 500 ml of acetone was added to the residue, and HCl gas was passed in while the mixture was cooled with ice. The resulting precipitate was filtered off under suction and dried to give 66 g (52.4%) of 1-N-diethylcarbamyl-4-methyl-5-chloroimidazole hydrochloride; mp. from 208° C., with decomposition.

Provenance & Evidence