Phenyl isocyanate → HCID 54079819, compound

Participants

Reaction Conditions

Reaction Steps

Using a procedure similar to that described in Example 1, 59.5 g of phenyl isocyanate were added dropwise to 58.5 g of 4-methyl-5-chloroimidazole in 250 ml of chloroform. During the addition, the temperature increased to 42° C. Refluxing was then carried out for 2 hours, after which the solution was cooled with ice, and the precipitate which separated out was filtered off under suction, washed with chloroform and dried to give 80 g (67.9%) of 1-N-phenylcarbamyl-4-methyl-5-chloroimidazole of melting point 112.3°-114.4° C.

Provenance & Evidence