Methyl Isocyanate → HCID 53998651, compound

Participants

Reaction Conditions

Reaction Steps

Using a procedure similar to that described in Example 1, 582.5 g of 4-methyl-5-chloroimidazole were dissolved in 1,500 ml of toluene at 70° C., and 313.5 g of methyl isocyanate were slowly run into the solution. During the addition, the temperature increased to about 90° C. Refluxing was then carried out for 30 minutes, after which the solution was cooled and then stirred for a further hour while being cooled with ice, and the precipitate which separated out was filtered off under suction, washed with ether and dried to give 826 g (95.2%) of 1-N-methylcarbamyl-4-methyl-5-chloroimidazole of melting point 95.6° C.

Provenance & Evidence