HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate | HCID 1235240 | — |
| Product | 2-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride | HCID 13282744 | — |
Reaction Steps
A mixture of 36.0 g (0.1554 mole) of the acid of Example 17 and 171 g (1.437 mole) of thionyl chloride were held at reflux for 6 hours. Excess thionyl chloride was removed under reduced pressure and the residue (38.1 g, 98%) was reacted as described in Examples 19-31.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04602937 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-a0f61152d1384babb9cba12f7a5cd96a |
| Source note | uspto-grants-1986_07 |