Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate → ethyl 2-Ethoxy-4-Trifluoromethyl-5-Thiazolecarboxylate

Participants

Reaction Conditions

Reaction Steps

To a cold (0° C.) solution of sodium ethoxide, prepared from 0.46 g (0.02 mole) of sodium and 40 ml. of dried ethanol, was added 5.2 g (0.02 mole) of ethyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate. A precipitate formed immediately. The reaction mixture was heated to 80° C. and then poured into ice water. The precipitate was collected to give 4.2 g (78%) of the desired product as a white solid, m.p. 30.5°-31.5° C.

Provenance & Evidence