反应详情

1-Aminopyridinium chloride (2.9 g) was added to 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoyl chloride (7.6 g) in acetonitrile (50 ml). The mixture was stirred and heated to reflux. After 20 minutes a solid precipitated. Reflux was continued for a further 40 minutes. Then the mixture was cooled in ice and the solid filtered off. The solid was washed with cold acetonitrile, then with ether, and was air dried to give 7.4 g of the desired product, mp 234°-237° C.

1. temperatureheated to reflux
2. customAfter 20 minutes a solid precipitated
3. temperatureReflux
4. temperatureThen the mixture was cooled in ice
5. filtrationthe solid filtered off
6. washThe solid was washed with cold acetonitrile
7. customdried