Putrescine → HCID 13577176, compound

Participants

Reaction Steps

13.225 Grams (150 mmoles) of putrescine (VI) was dissolved in 75 ml of tetrahydrofuran (THF), and a solution of 10.8 g (50 mmoles) of diacetyl-L-tartaric acid anhydride (VIII) in 50 ml of THF was gradually added dropwise thereto while cooling with ice under stirring. After addition, stirring was continued for 2 hours at room temperature, and after completion of the reaction, the solvent was removed by evaporation under reduced pressure. Thereafter, 50 ml of water was added, and the reaction solution was adjusted to pH 13 with 2N NaOH and stirred at room temperature for 2 hours to effect the hydrolysis of the acetyl group.

Provenance & Evidence