反应详情

温度

60 °C

A mixture of 18 g (80.9 mmoles) of 7-guanidinoheptanamide hydrochloride, 23.6 g (80.9 moles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride obtained in Example 4, and 5.7 g (27 mmoles) of citric acid in water (200 ml) was evaporated to dryness to give a syrup which contained 1.6 g of water. The resulting syrup was heated at 60° C. for 8 hours and purifiled in a procedure similar to that in Example 5 giving 19.0 g (47.3% yield) of white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(7-guanidinoheptanamido)-2-hydroxyethanamide trihydrochloride.

1. customwas evaporated to dryness
2. customto give a syrup which