HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → tert-butyl N-(2-methyl-1-oxopropan-2-yl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine | HCID 2733845 | — |
| Reactant | Bis(1-methylpiperazin-2-yl)alumanylium;hydride | HCID 18792082 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-butyl N-(2-methyl-1-oxopropan-2-yl)carbamate | HCID 14578674 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
N-Boc-2-aminoisobutyric acid is dissolved in tetrahydrofuran and stirred at 0° C. under argon. Bis(N-methylpiperazinyl)aluminum hydride is added and the reaction mixture heated to reflux overnight. Ether is then added, and the excess hydride is quenched with saturated NaCl. The aqueous phase is separated and extracted with ether. The combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl. The solution is dried over NaSO4 and evaporated to yield N-Boc-2-amino-2-methylpropanal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04603012 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-495b4441e2db4cb58edabd45f7f02e04 |
| Source note | uspto-grants-1986_07 |