反应详情

At 0° C. a solution of 5.8 mL pyridine and 15 mL tert.-butanol in 10 mL dichloromethane was added dropwise to 6.0 g 6-chloro-5-methyl-pyrimidine-4-carboxylic acid chloride in 10 mL dichloromethane. The reaction mixture was heated to RT and stirred for 30 min. The reaction mixture was diluted with dichloromethane and washed successively with a 2M sodium hydroxide solution, twice with a 10% aqueous citric acid solution and a sodium chloride solution. The organic phase was dried and evaporated down. The residue was taken up in dichloromethane and purified by flash chromatography. The product-containing fractions were evaporated down and dried.

1. washwashed successively with a 2M sodium hydroxide solution, twice with a 10% aqueous citric acid solution
2. customThe organic phase was dried
3. customevaporated down
4. custompurified by flash chromatography
5. customThe product-containing fractions were evaporated down
6. customdried