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Boron trifluoride etherate → HCID 20201229、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 反応物 | 2,2,4,4-Tetramethylpentan-3-ol | HCID 139790 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | HCID 13930700 | HCID 13930700 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 20201229 | HCID 20201229 | — |
反応手順
N-Cbz-2,2-Dimethyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and extracted with ethyl acetate. The organic layer is dried over MgSO4 and evaporated to yield N-Cbz-2-amino-2-methyl-1-[di-(t-butyl)-methoxy]propane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04603011 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-676cac46e0b3458993206ae20a536902 |
| 出典メモ | uspto-grants-1986_07 |