HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Z-Lys(Boc)-Phe-Phe-OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | IN2-(benzyloxycarbonyl)-N6-(tert-butoxycarbonyl)-L-lysine | HCID 98765 | — |
| Reactant | L-Phenylalanyl-L-phenylalanine | HCID 6993090 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Lys(Boc)-Phe-Phe-OH | HCID 131714787 | — |
Reaction Steps
4.19 g of Z-Lys(Boc)-OPc and 2.47 g of HCl.H-Phe-Phe-OH are taken up in 50 ml of dimethylformamide, 0.84 ml of N-ethylmorpholine are added and the whole is left to stand for 24 hours at 20°. The reaction mixture is concentrated by evaporation and the residue is triturated with water and dried over phosphorus pentoxide. Recrystallisation from ether yields crystals having a melting point of 154° to 156°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04603120 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-58f6271e8c0d42118b25fb5f5ea2c0ab |
| Source note | uspto-grants-1986_07 |