Hydrochloric Acid → HCID 13289763, compound

Participants

Reaction Steps

13.2 g (0.05 mol) of 1-cyclohexyl-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-pentan-3-one are dissolved in a mixture of 100 ml of methanol and 20 ml of water, a total of 2 g (0.05 mol) of sodium borohydride is added in several portions, and the mixture is stirred overnight. To work up the reaction mixture, it is brought to pH 5 with dilute hydrochloric acid, and the solvent is evaporated off in vacuo. The residue is taken up in water and extracted several times with methylene chloride. The combined organic extracts are washed with sodium bicarbonate solution and water, dried over sodium sulphate and evaporated down in vacuo. The residue is crystallized using petroleum ether. 10 g (75.2% of theory) of 1-cyclohexyl-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-pentan-3-ol are obtained in the form of colorless crystals of melting point 104° C. to 107° C.

Provenance & Evidence