2-Chloromethylbenzimidazole → HCID 13656995, compound

HRID 746211Notes

Reaction equation

HRID 746211 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl[CH2:10][C:11]1[NH:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1>>[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH2:10][C:11]2[NH:12][C:13]3[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=3[N:15]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 785712-ChloromethylbenzimidazoleHCID 2283491-Methylhomopiperazine

Product 1

HCID 13656995HCID 13656995, compoundYield 26%

Procedure

In the same manner as described in Reference Example 4, N-methylhomopiperazine (15 g) and 2-chloromethylbenzimidazole (10 g) are reacted, and the crude crystal thus obtained is recrystallized from toluene to give 2-(4-methyl-1-homopiperazinyl)methylbenzimidazole (3.81 g) as pale yellow prisms, m.p. 152°-155° C.

Workup

  1. customare reacted
  2. customthe crude crystal thus obtained
  3. customis recrystallized from toluene

Sources & evidence

ORD record
ord-48ddfa625aa048c286a0366467682e29
Source dataset
uspto-grants-1986_07
Patent number
US04603130

Reaction notes

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