HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloromethylbenzimidazole → 4-[(1H-Benzimidazol-2-yl)methyl]piperazine-1-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloromethylbenzimidazole | HCID 78571 | — |
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Product | 4-[(1H-Benzimidazol-2-yl)methyl]piperazine-1-carbaldehyde | HCID 13656997 | 78.1% |
Reaction Steps
In the same manner as described in Reference Example 4, N-formylpiperazine (17 g) and 2-chloromethylbenzimidazole (9.0 g) are reacted, and the crude crystal thus obtained is recrystallized from ethyl acetate to give 2-(4-formyl-1-piperazinyl)methylbenzimidazole (10.3 g) as pale yellow flakes, m.p. 194.5°-197.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04603130 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-1765005688244e80aa3dc2a72ee38e6f |
| Source note | uspto-grants-1986_07 |