Hexahydro-1,4-diazepine → HCID 13656992, compound

Participants

Reaction Steps

In the same manner as described in Example 1, homopiperazine (8.0 g) and 2-chloromethyl-1-(2-ethoxyethyl)benzimidazole (2.4 g) obtained in the same manner as described in Reference Example 3 are reacted to give 1-(2-ethoxyethyl)-2-(1-homopiperazinyl)methylbenzimidazole (2.0 g) as a pale yellow liquid. This liquid is treated with fumaric acid (1.15 g,), and the crude crystal thus obtained is recrystallized from a mixed solvent of ethyl acetate-ethanol to give 1-(2-ethoxyethyl)-2-(1-homopiperazinyl)methylbenzimidazole 3/2 fumarate (1.75 g) as colorless prisms, m.p. 151°-152° C.

Provenance & Evidence