1-Methylhomopiperazine → HCID 13656993, compound

Participants

Reaction Steps

In the same manner as described in Example 3, N-methylhomopiperazine (2.6 g) and 2-chloromethyl-1-(2-ethoxyethyl)benzimidazole (2.38 g) obtained in the same manner as described in Reference Example 3 are reacted to give 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)methylbenzimidazole (2.2 g) as a pale yellow liquid. This liquid is treated with fumaric acid (1.63 g), and the crude crystal thus obtained is recrystallized from a mixed solvent of ethyl acetate-ethanol to give 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)methylbenzimidazole 3/2 fumarate semihydrate (2.2 g) as colorless prisms, m.p. 119°-121.5° C.

Provenance & Evidence