1-Bromopropane → HCID 13656987, compound

Participants

Reaction Steps

A mixture of 1-(2-ethoxyethyl)-2-(1-piperazinyl)methylbenzimidazole (3.1 g) obtained in the same manner as described in Example 1, n-propyl bromide (2.0 g) and potassium carbonate (2.25 g) in ethanol (60 ml) is refluxed with stirring for 6.5 hours. The reaction mixture is treated in the same manner as described in Example 5 and the crude product is purified likewise to give 1-(2-ethoxyethyl)-2-(4-n-propyl-1-piperazinyl)methylbenzimidazole (3.1 g) as a pale brown liquid. This liquid is treated with fumaric acid (2.0 g), and the crude crystal thus obtained is recrystallized from ethanol to give 1-(2-ethoxyethyl)-2-4-n-propyl-1-piperazinyl)methylbenzimidazole 3/2 fumarate (3.9 g) as colorless needles, m.p. 178.5°-180° C.

Provenance & Evidence