Fumaric Acid → 1H-Benzimidazole, 2-((4-methyl-1-piperazinyl)methyl)-1-(2-propoxyethyl)-, (E)-2-butenedioate (1:2)

Participants

Reaction Steps

The above-obtained pale yellow solid [i.e. 1-(2-n-propoxyethyl)-2-(4-methyl-1-piperazinyl)methylbenzimidazole] (3.5 g) is treated with fumaric acid (2.57 g), and the crude crystal thus obtained is recrystallized from ethyl acetate-ethanol to give 1-(2-n-propoxyethyl)-2-(4-methyl-1-piperaziny)methylbenzimidazole difumarate (3.49 g) as colorless crystals, m.p. 160.5°-161.5° C.

Provenance & Evidence