HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 131714790, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | Boc-D-Nle-OH | HCID 6992559 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 131714790 | HCID 131714790 | 92.6% |
Reaction Steps
The title compound was prepared by the general method of Example 1 using 15.0 g (65 mmol) of t-butoxycarbonyl-D-norleucine (Boc-D-Nle) and 8.1 g (65 mmol) of glycine methyl ester hydrochloride. Trituration of the product oil with diethyl ether and (Skellysolve B) produced 18.2 g of the title compound as a pale yellow solid. Structure assignment was supported by elemental analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04603121 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-709a179fd69441f8897cf0f7e73819aa |
| Source note | uspto-grants-1986_07 |