(2S)-2-(((tert-butoxy)carbonyl)amino)-3-cyclohexylpropanoic acid → HCID 70403307, compound

HRID 746234Notes

Reaction equation

HRID 746234 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11](=[O:21])[C@H:12]([CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[NH2:13].C(OC(N[C@H](C(O)=O)CC1CCCCC1)=O)(C)(C)C.[C:42]([O:46][C:47]([NH:49][C@@H:50]([C:55]([NH:57][CH2:58][C:59](O)=[O:60])=[O:56])[CH2:51][CH2:52][CH2:53][CH3:54])=[O:48])([CH3:45])([CH3:44])[CH3:43]>>[C:42]([O:46][C:47]([NH:49][C@@H:50]([C:55]([NH:57][CH2:58][C:59]([NH:13][C@H:12]([C:11]([NH:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4]([O:3][CH3:2])=[O:22])=[O:21])[CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:60])=[O:56])[CH2:51][CH2:52][CH2:53][CH3:54])=[O:48])([CH3:45])([CH3:43])[CH3:44]

Participants

4

Reactant 3

HCID 10588189(2S)-2-(((tert-butoxy)carbonyl)amino)-3-cyclohexylpropanoic acidHCID 54230866HCID 54230866, compoundHCID 70402768HCID 70402768, compound

Product 1

HCID 70403307HCID 70403307, compound

Procedure

After preparing N-(6-methoxy-6-oxohexyl)-3-cyclohexyl-L-alaninamide monohydrochloride from the title product of Example 36 by the methods of Examples 1 and 3, the title compound was prepared by coupling this material with the title product of Example 99 using the general mixed anhydride procedure of Example 1. Structure assignment of the product isolated by chromotography was supported by elemental analysis.

Workup

  1. customStructure assignment of the product isolated by chromotography

Sources & evidence

ORD record
ord-09e57934df084980a0999c8636d91105
Source dataset
uspto-grants-1986_07
Patent number
US04603121

Reaction notes

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