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HRID746242

反应详情

EQUATION

反应方程式

HRID 746242 的结构方程式

REACTANTS

反应物

2
结构：C=C1CC(=O)O1
HCID12661

Diketene

C4H4O2

结构：OCCN1CCN(C(c2ccccc2)c2ccccc2)CC1
HCID4742573

4-(Diphenylmethyl)-1-piperazineethanol

C19H24N2O

PRODUCTS

生成物

1
结构：CC(=O)CC(=O)OCCN1CCN(C(c2ccccc2)c2ccccc2)CC1
HCID11740518

2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl 3-oxobutanoate

C23H28N2O3

PROCEDURE

实验过程

Diketene (5.1 g) was added to 4-benzhydryl-1-piperazineethanol (18.1 g) and the mixture was heated at 70°-80° C. with stirring for 1.5 hours and purified by silica gel chromatography [eluent: hexane-ethyl acetate (3:2)] to give 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate as an oil. Yield 17.1 g (73.6%).

WORKUP

后处理

  1. temperaturethe mixture was heated at 70°-80° C.
  2. custompurified by silica gel chromatography [eluent: hexane-ethyl acetate (3:2)]