4-Amino-2,2,6,6-tetramethylpiperidine → HCID 17015563, compound

HRID 746266Notes

Reaction equation

HRID 746266 reaction equation
[NH2:1][CH:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[NH:5][C:4]([CH3:11])([CH3:10])[CH2:3]1.[CH3:12][C:13]1[O:14][C:15]([CH3:21])=[CH:16][C:17]=1[C:18](Cl)=[O:19]>C1(C)C=CC=CC=1>[CH3:8][C:6]1([CH3:9])[CH2:7][CH:2]([NH:1][C:18]([C:17]2[CH:16]=[C:15]([CH3:21])[O:14][C:13]=2[CH3:12])=[O:19])[CH2:3][C:4]([CH3:11])([CH3:10])[NH:5]1

Participants

4

Reactant 2

HCID 375244-Amino-2,2,6,6-tetramethylpiperidineHCID 27348042,5-Dimethyl-3-furoyl Chloride

Product 1

HCID 17015563HCID 17015563, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

156 g (1 mole) of 4-amino-2,2,6,6-tetramethylpiperidine and 79 g (0.5 mole) of 2,5-dimethylfuran-3-carbonyl chloride in 1 l of toluene are refluxed for 24 hours, after which the precipitate is filtered off, the toluene solution is extracted by shaking with NaHCO3 solution and water, and is dried and evaporated down, and the residue is recrystallized from cyclohexane to give a product of melting point 116°-118° C.

Workup

  1. filtrationafter which the precipitate is filtered off
  2. extractionthe toluene solution is extracted
  3. customis dried
  4. customevaporated down
  5. customthe residue is recrystallized from cyclohexane
  6. customto give a product of melting point 116°-118° C.

Sources & evidence

ORD record
ord-2bfb66aed1704aa3b97e43ae0861656c
Source dataset
uspto-grants-1986_07
Patent number
US04603205

Reaction notes

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