Hydrochloric Acid → HCID 13711790, compound

Participants

Reaction Steps

A solution of 5-hexadecyloxy-2-tetrahydro pyranyloxymethyl-4-pyrone (1.1 g, 2.5 mmol) and HCl (10% in H2O, 10 ml) in THF (30 ml) was stirred at 25° overnight. TLC (ETAC/hexane: 3/7) indicated reaction was complete. The solution was diluted with ether (200 ml), washed with H2O (3×50 ml), 10% NaHCO3 (1×50 ml), sat'd NaCl (1×100 ml), dried (K2CO3) and concentrated to provide 0.88 g (98%) of 2-hydroxymethyl-5-hexadecyloxy-4-pyrone as a pure white solid mp 68.0°-69.5°.

Provenance & Evidence