HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-6,7-dimethoxycinnoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178419049 | HCID 178419049 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-6,7-dimethoxycinnoline hydrochloride | HCID 21991013 | — |
Reaction Steps
The starting material, 4-chloro-6,7-dimethoxycinnoline hydrochloride was obtained by heating a solution of 4-hydroxy-6,7-dimethoxycinnoline (1 g, 4.8 mmol) in thionyl chloride (20 ml) containing DMF (2 drops) at reflux for 3 hours. After cooling and evaporating the excess thionyl chloride, the solid was triturated with ether and filtered to give 4-chloro-6,7-dimethoxycinnoline hydrochloride (1.2 g, quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087602B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-4a0bf0cfcfb549828ce701f9b04db88c |
| Source note | uspto-grants-2006_08 |