反应详情

17.4 g of (2-tritylaminothiazol-4-yl)glyoxylic acid was dissolved in 500 ml of methanol under heating and the mixture was cooled to room temperature. A mixture of 100 ml of methanol and 5.5 g of 5-aminooxymethyl-1-methylimidazole was added to the mixture and then the resulting mixture was stirred overnight at room temperature. The precipitate formed was collected by filtration and washed with methanol to give 14.9 g of 2-(2-tritylaminothiazol-4-yl)-2-((1-methylimidazol-5-yl)methoxyimino)acetic acid with mp 231°-232° C. (decomposition).

1. temperatureunder heating
2. additionwas added to the mixture
3. customThe precipitate formed
4. filtrationwas collected by filtration
5. washwashed with methanol