1,4-Dioxane hydrochloride → HCID 69203803, compound

Participants

Reaction Steps

A solution of the product from Step C (4.53 g, 11.24 mmol) in 4N HCl/Dioxane (55 ML, 225 mmol) was stirred overnight. The solvent was evaporated to yield the 7-(trifluoromethyl)-1,2,3,4-tetrahydropyrido[3,4-d]pyridazine HCl salt (2.98 g, 100%). 1H-NMR (400 MHz, CD3OD) δ 8.63 (s, 1H), 7.78 (s, 1H), 4.80 (s, 2H), 4.48 (s, 2H). ESI-MS calc. For C8H8F3N3: 203.07; Found: 204 (M+H).

Provenance & Evidence