Potassium Hydroxide → HCID 11178647, compound

HRID 746447Notes

Reaction equation

HRID 746447 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:33])[C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:18]3[CH:20]=[C:21]([NH:24][CH2:25][C:26]([O:28]CC)=[O:27])[CH:22]=[CH:23][C:17]=3[O:16][C:15]=2[C:14]([O:31][CH3:32])=[CH:13][CH:12]=1)=[O:10].[OH-].[K+]>O.CO>[Cl:33][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:18]3[CH:20]=[C:21]([NH:24][CH2:25][C:26]([OH:28])=[O:27])[CH:22]=[CH:23][C:17]=3[O:16][C:15]=2[C:14]([O:31][CH3:32])=[CH:13][CH:12]=1)=[O:10]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 11397659HCID 11397659, compound

Product 1

HCID 11178647HCID 11178647, compoundYield 53.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

N-(3,5-dichloropyrid-4-yl)-4-methoxy-8-(2-ethoxy-2-oxo-ethylamino)-dibenzo[b,d]furan-1-carboxamide (Example 52) (100 mg, 0.204 mmol) was hydrolysed using potassium hydroxide (5 eq.) in 3 ml water and 3 ml methanol for 12 h at room temperature. The solid precitated was filted and washed with ethanol to obtain the product as pale yellow solid (50 mg). mp: >260° C.

Workup

  1. customfor 12 h
  2. customat room temperature
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-18f705dde19441edbaf2171f7ee2e295
Source dataset
uspto-grants-2008_07
Patent number
US07393846B2

Reaction notes

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