Triethylamine → HCID 59747866, compound

Participants

Reaction Conditions

Reaction Steps

After dissolving 0.34 g (1 mmole) [6-(3-amino-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(1H-indol-6-yl)-amine in 20 mL anhydrous THF, 3 equivalents of triethylamine are added and the reaction solution is cooled to 0° C. A solution of 0.2 g of 4-tert-butyl-benzoyl chloride (1 mmole) in 5 mL THF is added dropwise to the 0° C. reaction solution under N2. The ice bath is removed and the reaction is allowed to warm slowly to rt for 1 hr. Diethyl ether is then added slowly to the reaction solution and the resulting solid filtered and washed with diethyl ether to provide pure 4-tert-butyl-N-{3-[8-(1H-indol-6-ylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide.

Provenance & Evidence