HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Benzo[d]isoxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6,8-Dibromoimidazo[1,2-a]pyrazine | HCID 15025843 | — |
| Reactant | 6-Amino-1,2-benzisoxazole | HCID 45790038 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Benzo[d]isoxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine | HCID 59747864 | — |
Reaction Steps
A quantity of 0.13 g (1 mmole) of Benzo[d]isoxazol-6-ylamine is treated with 0.27 g (1 mmole) of 6,8-Dibromo-imidazo[1,2-a]pyrazine in acetonitrile with 3 eq. of K2CO3 at reflux for 16 hrs. The reaction mixture is cooled partitioned between ethyl acetate and water, the organic extracts are dried over anhydrous MgSO4 and evaporated in vacuo to afford Benzo[d]isoxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393848B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-115e97f6e6f14341b9d55ea867c1a4c9 |
| Source note | uspto-grants-2008_07 |