Cyclopropylamine → HCID 11174144, compound

HRID 746475Notes

Reaction equation

HRID 746475 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2/[CH:11]=[C:12]2\[C:13]([CH2:17][OH:18])([CH2:15][OH:16])[CH2:14]\2)=[C:4]([NH:19][CH:20]2[CH2:22][CH2:21]2)[N:3]=1.C1(N)CC1>>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2/[CH:11]=[C:12]2/[C:13]([CH2:17][OH:18])([CH2:15][OH:16])[CH2:14]/2)=[C:4]([NH:19][CH:20]2[CH2:22][CH2:21]2)[N:3]=1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 10086263HCID 10086263, compound

Product 1

HCID 11174144HCID 11174144, compoundYield 86%

Procedure

The procedure described for the Z-isomer 1h in Example 21 was followed with the E-isomer 2b and cyclopropylamine (0.70 mL, 5 mmol, 50° C., 20 h) to give compound 2h (130 mg, 86%).

Sources & evidence

ORD record
ord-20f2308dab894fbeaba416bf621f124d
Source dataset
uspto-grants-2008_07
Patent number
US07393855B2

Reaction notes

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