反应详情

705 mg (2.56 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 680 mg (2.56 mmol) (6-chloro-pyrimidin-4-yl)-(octahydro-indol-1-yl)-methanone and 0.871 mL (5 mmol) DIPEA were stirred in 10 mL DMF for 2 h at RT. The reaction mixture was purified by HPLC. The product-containing fractions were combined and the ACN was eliminated by rotary evaporation. The aqueous phase was made alkaline with 4M NaOH and extracted with EtOAc. The organic phase was dried, filtered and the filtrate was concentrated to dryness by rotary evaporation. The residue was crystallised from a mixture of MeOH and diethyl ether and the solid was suction filtered and dried.

1. customThe reaction mixture was purified by HPLC
2. customthe ACN was eliminated by rotary evaporation
3. extractionextracted with EtOAc
4. customThe organic phase was dried
5. filtrationfiltered
6. concentrationthe filtrate was concentrated to dryness by rotary evaporation
7. customThe residue was crystallised from a mixture of MeOH and diethyl ether
8. filtrationfiltered
9. customdried