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Triethylorthoaceate → N1-[3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylorthoaceate | HCID 21875354 | — |
| 反応物 | N1-{3-[(3-nitroquinolin-4-yl)amino]propyl}benzamide | HCID 23512704 | — |
| 生成物 | N1-[3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]benzamide | HCID 23512664 | — |
反応手順
Using the general method of Example 11 Part C, N1-{3-[(3-nitroquinolin-4-yl)amino]propyl}benzamide (2.0 g, 5.7 mmol) was reduced to the diamine and then reacted with triethylorthoacetate to provide 0.74 g of N1-[3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]benzamide as a sticky dark yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07393859B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-f452bcf2450e458584e880bdaa3166d6 |
| 出典メモ | uspto-grants-2008_07 |