HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine → n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine | HCID 23512719 | — |
| Reactant | N-Hydroxysuccinimido-d-biotin | HCID 129676281 | — |
| Product | n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide | HCID 23512652 | 75.2% |
Reaction Steps
Using the general method of Example 24, N-hydroxysuccinimidobiotin (0.6 g, 1.76 mmol) was reacted with 1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine (0.4 g, 1.76 mmol) to provide 0.6 g of N1-[2-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide as a solid, m.p. 169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393859B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-2a7a774ae67a47aa8ee005c109bb6571 |
| Source note | uspto-grants-2008_07 |