反应详情

Using the general method of Example 188 isoquinoline-3-caboxylic acid (1.05 g, 6.06 mmol) was reacted with 1-(3-aminopropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin4-amine (1.50 g, 5.01 mmol) to provide 1.30 g of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}isoquinoline-3-carboxamide as a white foam, m.p. 198.0-198.5° C. Analysis: Calculated for C26H26N6O2: % C, 68.71; % H, 5.77; % N, 18.49; Found: % C, 68.39; % H, 5.83; % N, 18.63.