Butyryl chloride → HCID 23512675, compound

Participants

Reaction Steps

Using the general method of Example 197, 1-(4-aminobutyl)-2-ethyl-1H-imidazo[4,5-c]quinolin-4-amine (1.00 g, 3.5 mmol) was reacted with butyryl chloride (0.40 mL, 3.9 mmol) to provide 0.77 g of N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]butanamide as a light brown solid, m.p. 147.7-148.8° C. Analysis: Calculated for C20H27N5O.0.4H2O: % C, 66.60; % H, 7.77; % N, 19.42; Found: % C, 66.84; % H, 7.77; % N, 19.36.

Provenance & Evidence